This descriptive research aims to study health impacts from PM 2.5. Perception of health impacts from PM 2.5 according to the Health Belief Model and self-protection behavior from PM 2.5. The sample consisted of people in Khon Kaen Municipality, Nai Mueang Subdistrict, Mueang District, Khon Kaen. Province. Data were collected by using questionnaires and were analyzed by using descriptive statistics. The results revealed that most of sample were female (63.2 percent) aged between 46-60 years (28.1 percent). Most were labour (39.9 percent), complete primary education (52.2%) and having an average monthly income of less than 5,000 baht / month (52.2 percent). The high risk group of people impacted by health, including people with chronic illnesses (25.8 percent), the elderly (18.4 percent) and pregnant women (3.9 percent). The sample were affected the health of PM 2.5 accounting for 49.1 percent. The perception of overall health impacts was at the moderate level of 53.5 percentage. The sample group perceived the risk of PM 2.5 hazard at a high level of 63.4 percent, perceived severity of the PM 2.5 problem was moderate at 53.5 percent, perceived benefits of protecting themselves from PM 2.5 was moderate level at 42.5 percent, perceived the obstacles in protecting themselves from PM 2.5 was low level at 53.9 percent, perceived the threat from PM 2.5 was high level at 67.5 percent, and also found that the samples had self - protection behavior from PM 2.5 at a moderate level, 37.7 percent. The suggestion from this study; relevant agencies should continually monitor and assess the health impacts of PM 2.5 and should campaign to educate more about PM 2.5 and how to protect themselves from PM 2.5 for a sustainable solution