Infraorbital hyperpigmentation becomes a significant concern in individual regardless of gender and age. The etiology of infraorbital hyperpigmentation is multifactorial including excessive pigmentation, periorbital volume loss, skin laxity and density of subcutaneous vasculature. Moreover, its management is quite challenging because multiple factors contribute this condition and choosing the appropriate treatment according to the causative factors. Among the causes, excessive pigmentation due to increased melanin is the most common factor. Niacinamide, one of the active forms of vitamin B3, possesses various properties such as skin lightening effect, anti-inflammatory, antioxidants and sebostatic effect. However, no clinical study that demonstrating the safety and efficacy of 5% Niacinamide cream for infraorbital area.