This research has the objectives to study the factors of technology acceptance and the quality of electronic services that affects the effectiveness of the e-Donation system of electronic donation units in the area of Nakhon Ratchasima Province Khon Kaen and Ubon Ratchathani Province The sample group was electronic donation units in 3 provinces in the area of Nakhon Ratchasima Province. Khon Kaen Ubon Ratchathani Province, 381 units received donations by using descriptive statistical data analysis Analyze using mean and standard deviation inferential statistics to test the hypothesis by using Regression Analysis, Multiple Regression Analysis. The research results found that: 1. Technology acceptance factor (β = 0.980*), processing aspect (β = 0.447*) and future utilization and analysis (β = 0.611*) had a positive effect on the effectiveness of the e -Donation system. of electronic donation units Statistically significant 0.05 2. The quality of electronic services (E-service) (β = 0.996*), privacy (β = 0.809*) and demand response (β = 0.805*) had a positive effect on the effectiveness of the system. e -Donation of electronic donation units Statistically significant 0.05