The objective was to examine self-care behavior of elderly and its relation to predisposing factor, enabling factor and reinforcing factor with self-care behaviors in Sila Sub-district, Muang Khon Kaen District, Khon Kaen Province.The sample through stratified random sampling, a total of 377. Data were collected using questionnaires interviewing and analysed using descriptive statistics, Spearman rank correlation analysis and Chi-square test. The research found that the elderlies’ were female, aged 60-69 years old, married, finished primary education, housekeeper/butler occupation, low self-care knowledge, good self-care behavior were 56.80%, 64.20%, 66.30%, 44.80%, 62.00%, 66.30% and 58.60%, respectively. Almost has a good attitude towards self-care, the average income per month was 7,500 baht. Mostly the elderlies’ had a chronic non-communicable diseases, access health resources at a high level and people around elderly gave importance to caring were 73.7%, 88.3% and 73.5% respectively. A correlation analysis revealed a negative relation between the age with self-care behavior of the elderly (rs = -.11, p = .03). On the other hand, a positive relation was found attitude towards self-care and access health resources with self-care behavior of the elderly (rs= .19, p < .001; rs = .11 , p = .02) and a positive relation between marital status with self-care behavior of the elderly (2= .13, p = .004) Suggestions to based on the results, there were the health service unit gave importance to the care of their health. Arrange suitable places and activities for health promotion for the elderly.