The purposes of this qualitative study were: 1) to study the management of the Rehabilitation Center for Disabled People in the community of Nong Kung SernSubdistrict, PhuWiang District, Khon Kaen Province, 2) to investigate problems and obstacles of the Rehabilitation Center for Disabled People in the development of disabled people in local area, and 3) to propose guidelines for the rehabilitation of disabled people's lives in the Rehabilitation Center for Disabled People. The data were obtained from 33 key informants from 3 groups: The disabled people and families include 15 families, 9 village headmen in 9 villages, and the President of Tambon Administration Organization, Director of District Hospital, Head of the Rehabilitation Center for Disabled People in the community, Community development personnel, volunteers taking care of disabled people include 9 persons, participated in focus group discussion and in-depth interview. The research tools used in the study were a structured – interview and frame for focus group discussion. The data were analyzed using content analysis. The results showed that: 1) the management of the Rehabilitation Center for Disabled People included medical rehabilitation, and occupation training, and providing knowledge concerning the people in public welfare such as receiving free treatment from government hospital, and subsidy for expenses in living expenses., 2) the problems and obstacles were found that most disabled people were not interested in vocational training because of living conditions. They were not interested in technology enhancements or other privileges that disabled people should receive on universal principles, such as being independent via technological devices for disabled people, and 3) the guidelines for development process of the Rehabilitation Center for Disabled People in Nong Kung SernSubdistrict, 3.1 the staff required the knowledge in the operation in various fields, such as physiotherapyshould volunteer for taking care of disabilities by home visit and transportation when they need help, 3.2 there should be coordination among other agencies. It was necessary to have government agencies to assess the services of the Center, 3.3 there should be promoting participation from the family member of disable persons in rehabilitation program and occupational training activities.