Abstract This research had the following objectives: (1) To study the status of management of Mahachulalongkornrajavidyalaya University (Khon Kaen Campus); (2) To analyze concepts of management of Mahachulalongkornrajavidyalaya University (Khon Kaen Campus) toward excellence in thenext deeade century; and (3) To propose a framework for management of Mahachulalongkornrajavidyalaya University. Data were drawn from 100 students of Mahachulalongkornrajavidyalaya University (Khon Kaen Campus) at the bachelor’s, master’s and doctoral level, by accidental sampling. The in-depth interviews were conducted with five University managers. This study had the following findings: (1) Management of the Mahachulalongkornrajavidyalaya University (Khon Kaen Campus) focuses on producing qualified graduates and personnel to meet the needs of the Sangha and society in developing the country. The focus is also on adding to the body of research and knowledge, while enhancing the arts and culture through academic management for the public good and developing students for the 21st century. (2) The level of management of the University is already at a high level (mean score of 4.66, S.D.=0.88). By components the means are 4.25 (S.D.=0.69) for arts and culture, 4.20 (S.D.=0.73) for academic management for society, 3.80 (S.D. = 0.87) for research, 3.70 (S.D. 0.92) for student preparedness for the 2ast century, and 3.65 (S.D. = 0.96) for production of successful graduates. (3) The framework for management by the University in the 21st century includes a review of the mission of the University to see what areas need strengthening to improve student preparedness. There will be a need to integrate all fields of study so that they achieve the same standard of quality and are up to the national qualifications and ideals. This will enable this Buddhist institution of higher education to be in step with the developments of this new century.