The purpose of this research were to study the effectiveness of the Blended Instructional Model to enhance Learning Outcomes and to study the satisfaction of nursing students on the Blended Instructional Model to enhance Learning Outcomes in the course of Ethics and Professional Laws for nursing students. Population were the 2nd year of nursing students, Academic year 2018, 97 students were registered in 602 203 Ethics and Professional Laws for nursing student. The research instruments were 1) 8 sets of pre-test online, 5 items per set, 40 items in total and multiple choice 2) 8 sets of post-test online, 3-5 items in total, totaling 30 Items and multiple choice, 3) 2 online tests as Midterm and Final Examination, 60 items per set and multiple choice and 4) the satisfaction form of the online rating scale 5 levels, 13 items. The IOC of content validity was 0.67-1.00 and the reliability was 0.91. Statistics using descriptive statistics of frequency, percentage, mean and standard deviation. The research found that The population is 97 nursing students in the academic year 2018, consisting of 97 people, 5 males, represented 5.15%, 92 females represented 94.85%, had learning outcomes in course of 602 203 Ethics and Profession Laws as follows: 1) Test scores Pre-test and Post-test had amount of student had higher answer. 2) The final examination average score higher than midterm examinations, and 3)The Nursing student was satisfied with the Blended Instructional Model to enhance Learning Outcomes in the highest level ( ̅ = 4.52, S.D. = 0.36)