This article aims to describe the pathophysiology and nursing care plan for patient of Acyanotic Congenital heart Disease: Case Study of Ventricular Septal Defect (VSD), which is a congenital heart disease with an incomplete ventricular septal defect. This is a cause to defect in the ventricular septum as the connection between the left and right ventricles. It is the most common congenital heart disease, ranging from 20% to 30% of all congenital heart disease, and also finding other types of associated lesions as well such as Aterial Septal Defect, Patent Ductus Ateriosus (PDA), and Pulmonary Stenosis (PS). Therefore, holistic nursing care for children with VSD, according to the nursing process which nurses must keep priority to solving problem and prevent the severity risk of disease to progression. Encourage children to have a quality of life according to appropriate development. And the family can take care of them effectively.